Yolk sac erythromyeloid progenitors expressing gain of function PTPN11 have functional features of JMML but are not sufficient to cause disease in mice.

Stefan P TarnawskyMomoko YoshimotoLisa DengRebecca J ChanMervin C Yoder

Published in: Developmental dynamics : an official publication of the American Association of Anatomists (2017)

YS EMPs expressing mutant PTPN11 demonstrate functional and molecular features of JMML but do not cause disease following transplantation nor following unperturbed development. Developmental Dynamics 246:1001-1014, 2017. © 2017 Wiley Periodicals, Inc.

Keyphrases

wild type
type diabetes
cell therapy
skeletal muscle
single molecule
mesenchymal stem cells