Acidic fibroblast growth factor inhibits reactive oxygen species-induced epithelial-mesenchymal transdifferentiation in vascular endothelial cells via the miR-155-5p/SIRT1/Nrf2/HO-1 pathway to promote wound healing in diabetic mice.

Yue ZhangFenghui HeiYujie XiaoYang LiuJuntao HanDahai HuHongtao Wang

Published in: Burns & trauma (2024)

In conclusion, our results suggest that aFGF inhibits ROS-induced epithelial-mesenchymal transdifferentiation in diabetic vascular endothelial cells via the miR-155-5p/SIRT1/Nrf2/HO-1 axis, thereby promoting wound healing.

Keyphrases

wound healing
high glucose
endothelial cells
oxidative stress
reactive oxygen species
diabetic rats
stem cells
bone marrow
type diabetes
dna damage
drug induced
cell death
vascular endothelial growth factor
cell proliferation
ionic liquid
signaling pathway