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Population Pharmacokinetics of Total Rabbit Anti-thymocyte Globulin in Non-obese Adult Patients Undergoing Hematopoietic Cell Transplantation for Hematologic Malignancy.

Takuto TakahashiMasahiro TeramotoKana MatsumotoMutaz M JaberHiroya TamakiKazuhiro IkegameSatoshi YoshiharaKatsuji Kaida
Published in: Clinical pharmacokinetics (2023)
This novel popPK model described the PK of total rATG in the adult HCT patients who received a low-dose rATG conditioning regimen. This model can be used for model-informed precision dosing in the settings with minimal baseline rATG targets (T cells), and early clinical outcomes are of interest.
Keyphrases
  • low dose
  • patients undergoing
  • adipose tissue
  • metabolic syndrome
  • young adults
  • cell death
  • bariatric surgery
  • cell proliferation
  • signaling pathway
  • childhood cancer