Genomic risk scores for juvenile idiopathic arthritis and its subtypes.

Rodrigo Cánovas Joanna CobbMarta BrozynskaJohn David BowesYun R LiSamantha Louise SmithHakon HakonarsonWendy ThomsonJustine A EllisGad AbrahamJane E MunroMichael Inouye

Published in: Annals of the rheumatic diseases (2020)

A GRS for JIA has potential to augment clinical JIA diagnosis protocols, prioritising higher-risk individuals for follow-up and treatment. Consistent with JIA heterogeneity, subtype-specific GRSs showed particularly high performance for enthesitis-related and oligoarthritis JIA.

Keyphrases

juvenile idiopathic arthritis
disease activity
systemic lupus erythematosus
single cell
risk assessment
climate change
human health
replacement therapy
drug induced