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Genomic risk scores for juvenile idiopathic arthritis and its subtypes.

Rodrigo CánovasJoanna CobbMarta BrozynskaJohn David BowesYun R LiSamantha Louise SmithHakon HakonarsonWendy ThomsonJustine A EllisGad AbrahamJane E MunroMichael Inouye
Published in: Annals of the rheumatic diseases (2020)
A GRS for JIA has potential to augment clinical JIA diagnosis protocols, prioritising higher-risk individuals for follow-up and treatment. Consistent with JIA heterogeneity, subtype-specific GRSs showed particularly high performance for enthesitis-related and oligoarthritis JIA.
Keyphrases
  • juvenile idiopathic arthritis
  • disease activity
  • systemic lupus erythematosus
  • single cell
  • risk assessment
  • climate change
  • human health
  • replacement therapy
  • drug induced