Unbiased Human Kidney Tissue Proteomics Identifies Matrix Metalloproteinase 7 as a Kidney Disease Biomarker.

Daigoro Hirohama Amin AbediniSalina MoonAditya SurapaneniSimon T Dillon Allison Vassalotti Hongbo Liu Tomohito Doke Victor J Martinez Zaipul Md DomAnil KarihalooMatthew B PalmerJosef Coresh Morgan E Grams Monika A Niewczas Katalin Suszták

Published in: Journal of the American Society of Nephrology : JASN (2023)

Our findings, which underscore the value of human kidney tissue proteomics analysis, identify kidney tissue MMP7 as a diagnostic marker of kidney fibrosis and blood MMP7 as a biomarker for future kidney function decline.

Keyphrases

endothelial cells
mass spectrometry
induced pluripotent stem cells
genome wide
label free
gene expression
current status