Genetic modifiers ameliorate endocytic and neuromuscular defects in a model of spinal muscular atrophy.

Melissa B WalshEva JanzenEmily WingroveSeyyedmohsen HosseinibarkooieNatalia Rodriguez MuelaLance DavidowMaria DimitriadiErika M NorabuenaLee L RubinBrunhilde WirthAnne C Hart

Published in: BMC biology (2020)

We propose that hnRNP F/H act in the same protein complex as PLS3 and SMN and that the function of this complex is critical for endocytic pathways, suggesting that hnRNP F/H proteins could be potential targets for therapy development.

Keyphrases

stem cells
gene expression
amino acid
dna methylation
copy number
human health
small molecule
climate change
chemotherapy induced