Risk of thrombosis with thrombocytopenia syndrome after COVID-19 vaccination prior to the recognition of vaccine-induced thrombocytopenia and thrombosis: A self-controlled case series study in England.
Hannah HigginsNick AndrewsJulia StoweGayatri AmirthalingamMary RamsayGurpreet BahraAnthony HackettKaren A BreenMichael J R DesboroughDalia KhanHeather LearyConnor SweeneyElizabeth HutchinsonSusan E ShapiroCharlotte LeesJay DhanapalPeter K MacCallumShoshana BurkeVickie McDonaldNgai Mun Aiman EntwistleStephen W BoothChristina J AtchisonBeverley Jane HuntPublished in: Research and practice in thrombosis and haemostasis (2022)
We demonstrate an increased risk of TTS in the 4 to 27 days following COVID-19 vaccination, particularly for ChAdOx1. These risks were lower than following SARS-CoV-2 infection. An alternative vaccine may be preferable in younger age groups in whom the risk of postvaccine TTS is greatest.