Off-label underdosing of four individual NOACs in patients with nonvalvular atrial fibrillation: A systematic review and meta-analysis of observational studies.

Chuanlan SangJiming ChenJunyi SunYuhui LaiXiao LiuWengen Zhu

Published in: European journal of clinical investigation (2022)

Off-label underdosing of rivaroxaban may increase the risk of stroke or systematic embolism, whereas off-label underdosing of apixaban may heighten the incidence of all-cause death.

Keyphrases

atrial fibrillation
oral anticoagulants
catheter ablation
left atrial
left atrial appendage
direct oral anticoagulants
heart failure
percutaneous coronary intervention
risk factors
venous thromboembolism
coronary artery disease
left ventricular
mitral valve
blood brain barrier