Regulation of exosome secretion by cellular retinoic acid binding protein 1 contributes to systemic anti-inflammation.

Yi-Wei LinJennifer NhieuChin-Wen WeiYu-Lung LinHiroyuki KagechikaLi-Na Wei

Published in: Cell communication and signaling : CCS (2021)

This study presents the first evidence for the regulation of exosome secretion, which mediates intercellular communication, by RA-Crabp1 signaling. This novel mechanism can contribute to the control of systemic inflammation by transferring an inflammatory regulator, RIP140, between cells. This represents a new mechanism of vitamin A action that can modulate the homeostasis of system-wide innate immunity without involving gene regulation. Video Abstract.

Keyphrases

oxidative stress
binding protein
induced apoptosis
transcription factor
systemic lupus erythematosus
systemic sclerosis
endoplasmic reticulum stress
interstitial lung disease
cell proliferation
cell adhesion
pi k akt