MX1 and UBE2L6 are potential metaflammation gene targets in both diabetes and atherosclerosis.
Guisheng WangRongrong HuaXiaoxia ChenXucheng HeYao DingmingHua ChenBuhuan ZhangYuru DongMuqing LiuJiaxiong LiuTing LiuJingwei ZhaoYu Qiong ZhaoLi QiaoPublished in: PeerJ (2024)
The global and internal PPI network of the 103 common DEGs consisted of 648 and 14 nodes, respectively. The intersection of the nodes of internal and global PPI networks was MX1 and UBE2L6, suggesting their key role in the comorbidity mechanism of DM and AS. This inference was partly verified by the overexpression of MX1 and UBE2L6 in the HC+STZ group but not others. Further calcium- and micronutrient-related enriched KEGG pathway analysis supported that MX1 and UBE2L6 may affect the inflammatory response through micronutrient metabolic pathways, conceptually named metaflammation. Collectively, MX1 and UBE2L6 may be potential common biomarkers for DM and AS that may reveal metaflammatory aspects of the pathological process, although proper validation is still needed to determine their contribution to the detailed mechanism.
Keyphrases
- inflammatory response
- cardiovascular disease
- type diabetes
- glycemic control
- genome wide
- single cell
- sentinel lymph node
- cell proliferation
- squamous cell carcinoma
- human health
- transcription factor
- adipose tissue
- immune response
- toll like receptor
- climate change
- neoadjuvant chemotherapy
- data analysis
- network analysis