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Reduction in TIMP-2 serum levels predicts remission of inflammatory bowel diseases.

Federico CarboneGiorgia BodiniMatteo BrunacciAldo BonaventuraAlessandra VecchièLuca LiberaleMattia CrespiIsabella BaldissarroFranco DallegriVincenzo SavarinoFabrizio MontecuccoEdoardo G Giannini
Published in: European journal of clinical investigation (2018)
This study indicates TIMP-2 reduction during IBD treatment with monoclonal anti-TNF-α antibodies as a potential prognostic parameter of short and long term remission. To understand if TIMP-2 is an innocent biomarker or an active pathophysiological factor in IBD remains to be clarified.
Keyphrases
  • ulcerative colitis
  • disease activity
  • rheumatoid arthritis
  • systemic lupus erythematosus
  • combination therapy
  • human health