Production of Four-Gene (GTKO/hCD55/hTBM/hCD39)-Edited Donor Pigs and Kidney Xenotransplantation.

Chang YangYunfang WeiXinglong LiKaixiang XuXiaoying HuoGang ChenHeng ZhaoJiaoxiang WangTaiyun WeiYubo QingJianxiong GuoHongfang ZhaoXiong ZhangDeling JiaoZhe XiongMuhammad Ameen JamalHong-Ye ZhaoHong-Jiang Wei

Published in: Xenotransplantation (2024)

These results indicate that the GTKO/hCD55/hTBM/hCD39 four-gene modification effectively alleviates immune rejection, and the pig kidney can functionally support the recipient monkey's life.

Keyphrases

copy number
genome wide
crispr cas
genome wide identification
gene expression
mouse model