The soluble guanylate cyclase stimulator IW-1973 prevents inflammation and fibrosis in experimental non-alcoholic steatohepatitis.

Roger Flores-CostaJosé Alcaraz-QuilesEsther TitosCristina López-VicarioMireia CasullerasMarta Duran-GüellBibiana RiusAlba DiazKatherine HallCourtney SheaRenee SarnoMark CurrieJaime L MasferrerJoan Claria

Published in: British journal of pharmacology (2018)

Our data indicate that sGC stimulation prevents hepatic steatosis, inflammation and fibrosis in experimental NASH. These findings warrant further evaluation of IW-1973 in the clinical setting.

Keyphrases

oxidative stress
liver fibrosis
mouse model
electronic health record
big data
machine learning
artificial intelligence