Proteomic profiling identifies novel circulating markers associated with bronchiectasis in cystic fibrosis.

Emily M DeBoerMiranda E KroehlBrandie D WagnerFrank J AccursoJ Kirk HarrisDavid A LynchScott D SagelRobin R Deterding

Published in: Proteomics. Clinical applications (2017)

Imaging outcomes were more strongly correlated with circulating proteins than age or spirometry values. The unique SOMAscan proteomic platform identifies several novel proteins in blood that are associated with bronchiectasis and that may serve as clinically useful biomarkers in children with CF.

Keyphrases

cystic fibrosis
lung function
pseudomonas aeruginosa
genome wide
high resolution
label free
young adults
single cell
dna methylation
gene expression
chronic obstructive pulmonary disease
skeletal muscle
insulin resistance
glycemic control