GGT5: a potential immunotherapy response inhibitor in gastric cancer by modulating GSH metabolism and sustaining memory CD8+ T cell infiltration.
Wenjing ZhaoZiwei LiangYongshi YaoYang GeGuangyu AnLing DuanJiannan YaoPublished in: Cancer immunology, immunotherapy : CII (2024)
Our study identifies GGT5, a hub gene in GSH metabolism, as a potential therapeutic target for inhibiting the response to immunotherapy in GC patients. These findings offer new insights into strategies for optimizing immunotherapy of GC.
Keyphrases
- end stage renal disease
- genome wide
- signaling pathway
- newly diagnosed
- fluorescent probe
- human health
- gene expression
- gas chromatography
- working memory
- risk assessment
- patient reported outcomes
- mass spectrometry
- patient reported
- transcription factor
- network analysis
- liquid chromatography
- genome wide analysis
- solid phase extraction