SARS-CoV-2 mRNA vaccines induce a greater array of spike-specific antibody isotypes with more potent complement binding capacity than natural infection.

Jéromine KlinglerGregory S LambertVincenza ItriSean LiuJuan C BandresGospel Enyindah-AsonyeXiaomei LiuKasopefoluwa Y OguntuyoFatima AmanatBenhur LeeSusan Zolla-PaznerChitra UpadhyayCatarina E Hioe

Published in: medRxiv : the preprint server for health sciences (2021)

Compared with natural infection, mRNA vaccines induced a greater array of IgG subtypes against spike in saliva and plasma. The vaccine-induced Abs were also more potent in mediating complement activation.

Keyphrases

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high glucose
diabetic rats
high resolution
high throughput
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drug induced
endothelial cells
transcription factor
stress induced