Impact of APOE ε4 genotype on initial cognitive symptoms differs for Alzheimer's and Lewy body neuropathology.

Jagan A PillaiJames BenaAaron Bonner-JacksonJames B Leverenz

Published in: Alzheimer's research & therapy (2021)

The odds of specific initial cognitive symptoms differed between ADP and LRP among APOE ε4 carriers compared to non-carriers. The odds of initial amnestic symptom was higher among ADP APOE ε4 carriers and the odds of visuospatial initial symptom was higher with LRP APOE ε4 carriers. This supports the hypothesis that APOE ε4 differentially impacts initial cognitive symptoms together with underlying neuropathology.

Keyphrases

cognitive decline
mild cognitive impairment
high fat diet
sleep quality
type diabetes
metabolic syndrome
insulin resistance
depressive symptoms
patient reported
skeletal muscle
low density lipoprotein