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Sirt3 restricts tumor initiation via promoting LONP1 deacetylation and K63 ubiquitination.

Liyi WuXinyi YanRuibo SunYe MaWanyu YaoBaogui GaoQingyuan ZhangJunxiong YouHao WangQinrui HanXue-Gang Sun
Published in: Journal of translational medicine (2023)
Sirt3 represents a targetable metabolic checkpoint of oncogenesis, which produces energy restriction effects via maintaining LONP1 K145 deacetylation and subsequent K63 ubiquitination.
Keyphrases
  • oxidative stress
  • ischemia reperfusion injury
  • dna damage
  • cell cycle