A genetic variant near GATA3 implicated in inherited susceptibility and etiology of benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS).

Rong NaBrian T HelfandHaitao ChenCarly A ConranSusan E CrawfordSimon W HaywardTeuvo L J TammelaJudy Hoffman-BoltonSiqun L ZhengPatrick C WalshJohanna SchleutkerElizabeth A PlatzWilliam B IsaacsJianfeng Xu

Published in: The Prostate (2017)

Rs17144046 located near GATA3 was significantly associated with BPH/LUTS in three independent populations, but did not reach a stringent GWAS significance level. Genetic variants of GATA3 may play a role in the inherited susceptibility and etiology of BPH/LUTS. Further research in this area is needed.

Keyphrases

lower urinary tract symptoms
benign prostatic hyperplasia
transcription factor
genome wide
genome wide association study