T-bet+CD11c+ B cells are critical for antichromatin immunoglobulin G production in the development of lupus.

Ya LiuShiyu ZhouJie QianYan WangXiang YuDai DaiMin DaiLingling WuZhuojun LiaoZhixin XueJiehua WangGoujun HouJianyang MaJohn B HarleyYuanjia TangNan Shen

Published in: Arthritis research & therapy (2017)

T-bet+CD11c+ B cells promoted high antichromatin IgG production in the lupus-like disease model cGVHD. In lupus patients, the percentage of T-bet+CD11c+ B cells was elevated and positively correlated with antichromatin antibodies. The findings provide potential therapeutic insight into lupus disease treatment.

Keyphrases

systemic lupus erythematosus
disease activity
end stage renal disease
rheumatoid arthritis
newly diagnosed
ejection fraction
nk cells
chronic kidney disease
peritoneal dialysis