Diagnostic Value of Vascular Endothelial Growth Factor, Transforming Growth Factor-β, Interleukin-8, and the Ratio of Lactate Dehydrogenase to Adenosine Deaminase in Pleural Effusion.
Takeshi SarayaKosuke OhkumaTakayasu WatanabeSunao MikuraFumi KobayashiJunpei AsoHiroki NunokawaKojiro HondaYukari OgawaMasaki TamuraMitsuru SadaMiku OdaManami InoueTakuma YokoyamaDaisuke KuraiHaruyuki IshiiHirokazu KimuraHajime TakizawaPublished in: Lung (2018)
VEGF and IL-8 production in the pleural cavity appear to accelerate the progression of PPE to empyema, by enhancing vascular permeability associated with inflammation. Sequential sampling would be needed to confirm this. The pleural LDH/ADA ratio may be a useful diagnostic tool for discriminating between various pleural effusion etiologies.