Prospective Quantification of CSF Biomarkers in Antibody-Mediated Encephalitis.

Gregory S DayMelanie Y YarbroughPéter KörtvélyessyHarald PrüssRobert C BucelliMarvin J FritzlerWarren MasonDavid F Tang-WaiClaude SteriadeJulien HébertRachel L HensonElizabeth M HerriesJack H LadensonA Sebastian Lopez-ChiribogaNeill R Graff-RadfordJohn C MorrisAnne Fagan

Published in: Neurology (2021)

CSF biomarkers suggest that neuronal integrity is acutely maintained in AME, despite neuroaxonal compromise. Low levels of biomarkers of synaptic function may reflect antibody-mediated internalization of cell surface receptors and may represent an acute correlate of antibody-mediated synaptic dysfunction, with the potential to inform disease severity and outcomes.

Keyphrases

cell surface
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oxidative stress
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respiratory failure
climate change
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adipose tissue
aortic dissection