Neuroproteomic mapping of kinases and their substrates downstream of acetylcholine: finding and implications.
Yukie YamahashiDaisuke TsuboiYasuhiro FunahashiKozo KaibuchiPublished in: Expert review of proteomics (2023)
The elucidation of signaling pathways beyond M1R by phosphoproteomic approach offers a platform for understanding the intracellular mechanism of AD drugs and for developing AD therapeutic strategies. Clarifying the molecular mechanism that links the identified acetylcholine signaling to AD pathophysiology will advance the development of AD therapeutic strategies.