Rosuvastatin-Eluting Gold Nanoparticle-Loaded Perivascular Implantable Wrap for Enhanced Arteriovenous Fistula Maturation in a Murine Model.
Carleigh KlusmanBenjamin MartinJoy Vanessa D PerezAllan John R BarcenaMarvin R BernardinoErin Marie D San ValentinJossana A DamascoHuckie C Del MundoKarem A CourtBiana GodinNatalie Wall FowlkesRichard R BouchardJizhong ChengSteven Y HuangMarites P MelanconPublished in: bioRxiv : the preprint server for biology (2023)
The reduced NIH seen with ROSU-loading of perivascular wraps suggests a synergistic effect between mechanical support and anti-hyperplasia medication. Furthermore, the addition of AuNPs increased wrap radiopacity. Together, our results show that radiopaque, AuNP-, and ROSU-loaded PCL grafts induce AVF maturation and suppress NIH while facilitating optimal implanted device visualization.