Mixed IgG Fc immune complexes exhibit blended binding profiles and refine FcR affinity estimates.

Zhixin Cyrillus TanAnja Lux Markus BiburgerPrabha VargheseStephen LeesFalk Nimmerjahn Aaron S Meyer

Published in: bioRxiv : the preprint server for biology (2023)

The binding behavior of mixed Fc immune complexes is a blend of the binding properties for each constituent IgG species.An equilibrium, multivalent binding model can be generalized to incorporate immune complexes of mixed Fc composition.Particularly for low-affinity IgG-Fcγ receptor interactions, immune complexes provide better estimates of affinities.The FcγR binding model predicts effector-elicited cell clearance in humanized mice.

Keyphrases

binding protein
dna binding
type diabetes
metabolic syndrome
adipose tissue
regulatory t cells
cell therapy
molecular dynamics
dendritic cells
molecular dynamics simulations
insulin resistance
high fat diet induced
genetic diversity