Effects of trastuzumab and trastuzumab emtansine on corrected QT interval and left ventricular ejection fraction in patients with metastatic (HER2+) breast cancer.

Rea LevickiMartina Lovrić BenčićIrena Ivanac VranešićLada BradićMarta BegovacJuraj JugNatalija Dedić Plavetić

Published in: The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology (2023)

Trastuzumab and trastuzumab emtansine cardiotoxicity manifested as a significant and progressive QTc prolongation after successive drug applications, reaching the peak value just before the fifth cycle of both drugs. Both medications also caused statistically significant but asymptomatic LVEF reduction. Complete reversibility of cardiotoxic effects of both drugs was confirmed by QTc interval and LVEF normalisation after the treatment discontinuation.

Keyphrases

metastatic breast cancer
ejection fraction
epidermal growth factor receptor
aortic stenosis
drug induced
left ventricular
multiple sclerosis
heart failure
tyrosine kinase
acute coronary syndrome
coronary artery disease
combination therapy
left atrial
young adults
smoking cessation