Causal effects of gut microbiota on sepsis and sepsis-related death: insights from genome-wide Mendelian randomization, single-cell RNA, bulk RNA sequencing, and network pharmacology.

Sha YangJing GuoZhuo KongMei DengJingjing DaXin LinShuo PengJunwu FuTao LuoJun MaHao YinLin LiuJian LiuYan ZhaYing TanJiqin Zhang

Published in: Journal of translational medicine (2024)

Our study provides insights for the development of personalized treatment strategies for sepsis and offers preliminary candidate targets and drugs for future drug development.

Keyphrases

single cell
septic shock
acute kidney injury
intensive care unit
genome wide
rna seq
high throughput
current status
gene expression
copy number
drug induced