Associations of genetics, behaviors, and life course circumstances with a novel aging and healthspan measure: Evidence from the Health and Retirement Study.
Zuyun LiuXi ChenThomas M GillChao MaEileen M CrimminsMorgan E LevinePublished in: PLoS medicine (2019)
In a sample of US older adults, genetic, behavioral, and socioenvironmental circumstances during childhood and adulthood account for about 30% of differences in phenotypic aging. Our results also suggest that the detrimental effects of disadvantaged life course circumstances for health and aging may be further exacerbated among persons with genetic predisposition to coronary artery disease. Finally, our finding that behaviors had the largest contribution to PhenoAge highlights a potential policy target. Nevertheless, further validation of these findings and identification of causal links are greatly needed.
Keyphrases
- public health
- healthcare
- coronary artery disease
- mental health
- genome wide
- health information
- human health
- physical activity
- copy number
- health promotion
- cardiovascular disease
- percutaneous coronary intervention
- gene expression
- cardiovascular events
- risk assessment
- atrial fibrillation
- left ventricular
- childhood cancer