Obesity and Multiple Sclerosis: A Mendelian Randomization Study.

Lauren E MokryStephanie RossNicholas John Timpson Stephen J SawcerGeorge Davey SmithJ Brent Richards

Published in: PLoS medicine (2016)

Genetically elevated BMI is associated with risk of MS, providing evidence for a causal role for obesity in MS etiology. While obesity has been associated with many late-life outcomes, these findings suggest an important consequence of childhood and/or early adulthood obesity.

Keyphrases

multiple sclerosis
insulin resistance
metabolic syndrome
weight loss
weight gain
high fat diet induced
type diabetes
mass spectrometry
ms ms
adipose tissue
depressive symptoms
physical activity
white matter
early life
young adults