Resveratrol Improves Hyperuricemia and Ameliorates Renal Injury by Modulating the Gut Microbiota.
Yuqing ZhouYupeng ZengRuijie WangJuan PangXin WangZhijun PanYufeng JinYu ChenYan YangWenhua LingPublished in: Nutrients (2024)
Resveratrol (RES) has been reported to prevent hyperuricemia (HUA); however, its effect on intestinal uric acid metabolism remains unclear. This study evaluated the impact of RES on intestinal uric acid metabolism in mice with HUA induced by a high-fat diet (HFD). Moreover, we revealed the underlying mechanism through metagenomics, fecal microbiota transplantation (FMT), and 16S ribosomal RNA analysis. We demonstrated that RES reduced the serum uric acid, creatinine, urea nitrogen, and urinary protein levels, and improved the glomerular atrophy, unclear renal tubule structure, fibrosis, and renal inflammation. The results also showed that RES increased intestinal uric acid degradation. RES significantly changed the intestinal flora composition of HFD-fed mice by enriching the beneficial bacteria that degrade uric acid, reducing harmful bacteria that promote inflammation, and improving microbial function via the upregulation of purine metabolism. The FMT results further showed that the intestinal microbiota is essential for the effect of RES on HUA, and that Lactobacillus may play a key role in this process. The present study demonstrated that RES alleviates HFD-induced HUA and renal injury by regulating the gut microbiota composition and the metabolism of uric acid.
Keyphrases
- uric acid
- high fat diet
- metabolic syndrome
- insulin resistance
- adipose tissue
- oxidative stress
- high fat diet induced
- signaling pathway
- microbial community
- stem cells
- cell proliferation
- type diabetes
- mesenchymal stem cells
- small molecule
- diabetic rats
- drug induced
- bone marrow
- protein protein
- binding protein
- stress induced
- diabetic nephropathy
- wild type