Syringic acid ameliorates ischemia/reperfusion-induced testicular injury in rats via suppressing of HMGB1/NF-κB axis and endoplasmic reticulum stress.

Elif Ayazoglu DemirSelim DemirIlke Onur KazazHatice KucukNihal Turkmen AlemdarOmer Faruk GeciciAhmet MenteseYuksel Aliyazicioglu

Published in: European journal of trauma and emergency surgery : official publication of the European Trauma Society (2023)

The overall results suggest that syringic acid emerges as a potential compound for the treatment of testicular torsion and may be subject to clinical trials.

Keyphrases

endoplasmic reticulum stress
induced apoptosis
clinical trial
signaling pathway
germ cell
diabetic rats
high glucose
oxidative stress
lps induced
mouse model
pi k akt
combination therapy
cell proliferation
human health
phase iii