IL-4Rα blockade reduces influenza-associated morbidity in a murine model of allergic asthma.

Kimia ShahangianDavid A NganH H Rachel ChenYeni OhAnthony TamJing WenChung CheungDarryl A KnightDelbert R DorscheidTillie L HackettMichael R HughesKelly M McNagnyJeremy A HirotaMasahiro NiikuraS F Paul ManDon D Sin

Published in: Respiratory research (2021)

Together, these data implicate allergic asthma as a significant risk factor for H1N1-related morbidity and reveal a potential therapeutic role for IL-4Rα signalling blockade in reducing the severity of influenza infection in those with allergic airway disease.

Keyphrases

allergic rhinitis
chronic obstructive pulmonary disease
lung function
electronic health record
atopic dermatitis
genome wide
machine learning
cystic fibrosis
air pollution
drug induced