Electroacupuncture ameliorates mechanical hypersensitivity by down-regulating spinal Janus kinase 2/signal transducer and activation of transcription 3 and interleukin 6 in rats with spared nerve injury.

Ying WangYang-Yang XiaMeng XueQian JiangZhihua HuangCheng Huang

Published in: Acupuncture in medicine : journal of the British Medical Acupuncture Society (2020)

This study revealed that 2 Hz EA attenuated SNI-induced mechanical hypersensitivity and the concomitant up-regulation of spinal JAK2, STAT3 and IL-6 in SNI rats, suggesting that suppression of the JAK2/STAT3 signaling pathway might be the mechanism underlying the therapeutic effect of 2 Hz EA on neuropathic pain.

Keyphrases

neuropathic pain
spinal cord
spinal cord injury
drug induced
signaling pathway
high glucose
transcription factor
epithelial mesenchymal transition
endothelial cells
tyrosine kinase
single cell
cell proliferation
protein kinase
peripheral nerve
brain injury
induced apoptosis