Time-restricted feeding downregulates cholesterol biosynthesis program via RORγ-mediated chromatin modification in porcine liver organoids.

Kexin ZhangHao LiZimeng XinYanwei LiXiaolong WangYun HuHaoyu LiuDemin Cai

Published in: Journal of animal science and biotechnology (2020)

Our findings demonstrate that TRF triggers the RORγ-mediated chromatin remodeling at the locus of CHO biosynthesis genes in porcine liver organoids and further improves lipid metabolism.

Keyphrases

genome wide
gene expression
dna damage
transcription factor
cell wall
quality improvement
genome wide identification