TLR4 inhibitor TAK-242 attenuates the adverse neural effects of diet-induced obesity.
V Alexandra MoserMariana F UchoaChristian J PikePublished in: Journal of neuroinflammation (2018)
These results demonstrate a significant protective effect of TLR4 inhibition on neural consequences of obesity, findings that further define the role of microglia in obesity-mediated outcomes and identify a strategy for improving brain health in obese individuals.
Keyphrases
- weight loss
- metabolic syndrome
- insulin resistance
- type diabetes
- inflammatory response
- high fat diet induced
- toll like receptor
- weight gain
- adipose tissue
- immune response
- healthcare
- public health
- mental health
- health information
- nuclear factor
- emergency department
- neuropathic pain
- skeletal muscle
- physical activity
- social media
- health promotion