A study of disseminated intravascular coagulation in acute leukemia reveals markedly elevated D-dimer levels are a sensitive indicator of acute promyelocytic leukemia.

N ShahmarvandJ S OakMichael J CascioM AlcasidE GoodmanB C MedeirosD A ArberJ L ZehnderRobert S Ohgami

Published in: International journal of laboratory hematology (2017)

Overall we identify elevated D-dimer concentrations ≥19 000 ng/mL FEU are a sensitive indicator of acute promyelocytic leukemia (APL), with a sensitivity of 96% and specificity of 92% in the subtyping of acute leukemias, and that the presence of schistocytes in peripheral blood smears is not a diagnostically sensitive screening test for DIC with a sensitivity of 36%.

Keyphrases

liver failure
respiratory failure
peripheral blood
aortic dissection
drug induced
acute myeloid leukemia
bone marrow
coronary artery
hepatitis b virus
intensive care unit