Validation in a Brazilian population of gene markers of periodontitis previously investigated by GWAS and bioinformatic studies.

Thamiris CirelliRafael NepomucenoSilvana R P OrricoCarlos RossaJoni A CirelliKari E NorthMariaelisa GraffSilvana P BarrosRaquel Mantuaneli Scarel Caminaga

Published in: Journal of periodontology (2020)

This is the first evidence of validation in a Brazilian population of genetic markers of periodontitis previously investigated by GWAS and bioinformatics studies. SNPs in the NPY, IL37, and NCR2 genes were associated with susceptibility to moderate or severe periodontitis; whereas the TLR9 marker was associated with lower chance to develop severe periodontitis. Those SNPs had sex- and smoking-habit-specific effects on periodontitis; reinforcing the genetic profile predisposing to periodontitis.

Keyphrases

genome wide
copy number
dna methylation
early onset
immune response
inflammatory response
toll like receptor
gene expression
atomic force microscopy
case control
transcription factor
high resolution
high intensity
genome wide analysis
nuclear factor