Immunoproteasome subunit β5i promotes perifascicular muscle atrophy in dermatomyositis by upregulating RIG-I.

Lu ZhangQisheng XiaWenli LiQingyan LiuLining ZhangXiaolan TianLifang YeGuochun WangQing-Lin Peng

Published in: RMD open (2023)

The immunoproteasome subunit β5i promotes perifascicular muscle atrophy in DM via RIG-I upregulation; our findings suggest a pathomechanistic role of β5i and RIG-I in DM-associated muscle damage, highlighting these components as potential therapeutic targets for the treatment of DM.

Keyphrases

skeletal muscle
glycemic control
oxidative stress
cell proliferation
interstitial lung disease
protein kinase
systemic sclerosis
insulin resistance
disease activity
weight loss
idiopathic pulmonary fibrosis