Experimental parameters and infarct size in closed chest pig LAD ischemia reperfusion models; lessons learned.
Max J M SilvisGerardus P J van HoutAernoud T L FioletMirthe DekkerLena BoschMartijn M J van NieuwburgJoyce VisserMarlijn S JansenLeo TimmersDominique P V de KleijnPublished in: BMC cardiovascular disorders (2021)
These experiments describe the association of occlusion time, follow-up duration, AAR and VF with IS in closed chest pig LAD I/R models. These results have important implications for future I/R studies in pigs and can serve as a guideline for the selection of appropriate parameters and the optimal experimental design.