Duration of Adjunctive Antidepressant Maintenance in Bipolar I Depression.
Lakshmi N YathamShyam Sundar ArumughamMuralidharan KesavanKanchana RamachandranNithyananda S MurthyGayatri SarafYongdong OuyangDavid J BondAyal SchafferArun RavindranNisha RavindranBenicio N FreyAndrée DaigneaultSerge BeaulieuRaymond W LamNithin KondapuramM S ReddyR P BhandaryMysore V AshokKyooseob HaYong Min AhnRoumen MilevHubert WongY C Janardhan Reddynull nullPublished in: The New England journal of medicine (2023)
In a trial involving patients with bipolar I disorder and a recently remitted depressive episode, adjunctive treatment with escitalopram or bupropion XL that continued for 52 weeks did not show a significant benefit as compared with treatment for 8 weeks in preventing relapse of any mood episode. The trial was stopped early owing to slow recruitment and funding limitations. (Funded by the Canadian Institutes of Health Research; ClinicalTrials.gov number, NCT00958633.).