Actin cytoskeleton remodeling drives epithelial-mesenchymal transition for hepatoma invasion and metastasis in mice.

Jei-Ming PengRabindranath BeraChih-Yung ChiouMing-Chin YuTse-Chin ChenChia-Wei ChenTsung-Rui WangWan-Ling ChiangShin-Pei ChaiYongkun WeiHuamin WangMien-Chie HungSen-Yung Hsieh

Published in: Hepatology (Baltimore, Md.) (2018)

Simultaneously activation of actin cytoskeleton remodeling by intrinsic (such as KLHL23 down-regulation) or microenvironment cues is crucial for cell-density-dependent and hypoxia-mediated EMT, providing a mechanistic link between large tumor size and invasion/metastasis. Our findings provide a means of developing the prevention and treatment strategies for tumor invasion and metastasis. (Hepatology 2018;67:2226-2243).

Keyphrases

cell migration
epithelial mesenchymal transition
transforming growth factor
stem cells
single cell
signaling pathway
endothelial cells
high fat diet induced