Comparison of 4F-PCC in obese and nonobese patients with life-threatening bleeding or requiring emergent surgery.
Jessica RimsansKaren BergerSarah CulbrethChristopher HoodKatleen ChesterJean Marie ConnorsLaurel OmertPublished in: Research and practice in thrombosis and haemostasis (2021)
In those >100 kg, we found no difference in achieving international normalized ratio (INR) ≤1.3, hemostasis in intracranial hemorrhage, or thrombosis. In-hospital mortality occurred 15% in LoWt versus 6% in HiWT (CI 1.8%-17%, p = 0.034). Achievement of INR ≤ 1.5 was significantly lower in the LoWT group compared to the HiWT group (80% versus 91%, CI -20% to -2.5%, p = 0.03).