Hippocalcin-like 1 is a key regulator of LDHA activation that promotes the growth of non-small cell lung carcinoma.

Xiangyu WangXiaomeng XieYuanyuan ZhangFayang MaMengjun PangKyle Vaughn LasterXiang LiKangdong LiuZigang DongDong Joon Kim

Published in: Cellular oncology (Dordrecht) (2022)

Our data indicate that the effect of HPCAL1 knockdown on reducing SRC-mediated LDHA activity attenuates NSCLC growth. Our findings reveal novel biological functions and a mechanism underlying the role of HPCAL1 in NSCLC growth in vitro and in vivo.

Keyphrases

small cell lung cancer
single cell
advanced non small cell lung cancer
transcription factor
stem cells
big data
mesenchymal stem cells
machine learning
artificial intelligence
deep learning