Dual Effect of PER2 C111G Polymorphism on Cognitive Functions across Progression from Subjective Cognitive Decline to Mild Cognitive Impairment.

Salvatore Mazzeo Valentina BessiSilvia BagnoliGiulia GiacomucciJuri BalestriniSonia PadiglioniGiulia TomaiuoloAssunta IngannatoCamilla FerrariLaura BraccoSandro SorbiBenedetta Nacmias

Published in: Diagnostics (Basel, Switzerland) (2021)

PER2 C111G polymorphism is associated with better language performance in SCD patients. Nevertheless, as patients progress to MCI, G allele carriers showed a greater worsening in cognitive performance compared to G non-carriers. The effect of PER2 C111G polymorphism depends on the global cognitive status of patients.

Keyphrases

mild cognitive impairment
cognitive decline
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
depressive symptoms
patient reported outcomes