ADAR1 Inhibits Macrophage Apoptosis and Alleviates Sepsis-induced Liver Injury Through miR-122/BCL2A1 Signaling.
Shanshou LiuJiangang XieChujun DuanXiaojun ZhaoZhusheng FengZheng DaiXu LuoYu LiMinghe YangRan ZhuangJunjie LiKuo ShenPublished in: Journal of clinical and translational hepatology (2023)
The findings show that ADAR1 alleviates macrophage apoptosis and sepsis-induced liver damage through the miR-122/BCL2A1 signaling pathway. The study provides novel insights into the development of therapeutic interventions in sepsis.
Keyphrases
- oxidative stress
- septic shock
- acute kidney injury
- cell proliferation
- intensive care unit
- long non coding rna
- signaling pathway
- endoplasmic reticulum stress
- cell cycle arrest
- long noncoding rna
- diabetic rats
- adipose tissue
- pi k akt
- cell death
- induced apoptosis
- mouse model
- physical activity
- epithelial mesenchymal transition