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Inflammatory bowel disease associated with primary sclerosing cholangitis is associated with an altered gut microbiome and bile acid profile.

Haim LeibovitzhShadi NayeriKrzysztof BorowskiCristian Hernandez-RochaSun-Ho LeeWilliams TurpinJoanne M StempakIqbaljit SandhuRaquel MilgromMichelle I SmithKenneth CroitoruGideon M HirschfieldAliya GulamhuseinMark S Silverberg
Published in: Journal of Crohn's & colitis (2024)
We identified differences in microbial species, functional capacity and serum BA profiles in IBD-PSC compared with IBD-only. Our findings provide insight into the pathophysiology of IBD associated with PSC and suggest possible targets for modulating the risk and course of IBD in subjects with PSC.
Keyphrases
  • ulcerative colitis
  • microbial community
  • signaling pathway