The Performance of the Abbott Real Time MTB RIF/INH Compared to the MTBDRplus V2 for the Identification of MDR-TB Among Isolates.

Anura DavidLyndel SinghManuel Pedro da Silva Lesley Erica ScottWendy Stevens

Published in: Infection and drug resistance (2020)

Overall, the RT MTB RIF/INH demonstrated good agreement with the LPA, and a better correlation with sequencing on discrepant isolates specifically with mutations occurring in codon 511 of the rpoB gene. The RT MTB RIF/INH therefore can be used to complement existing laboratory algorithms determining Rif and INH resistance profiles, with less emphasis on manual laboratory processing.

Keyphrases

pulmonary tuberculosis
mycobacterium tuberculosis
machine learning
genetic diversity
multidrug resistant
deep learning
copy number
genome wide analysis