Activation of miR-500a-3p/CDK6 axis suppresses aerobic glycolysis and colorectal cancer progression.

Yu LiuWentao TangLi RenTianyu LiuMeng YangYe WeiYijiao ChenMeiling JiGuosong ChenWenju ChangJianmin Xu

Published in: Journal of translational medicine (2022)

Our study revealed a potential tumor-suppressive role of miR-500a-3p in CRC, specifically targeting CDK6 and inhibiting cancer cell proliferation and aerobic glycolysis, which may provide new insights into novel prognostic biomarkers and therapeutic targets for CRC.

Keyphrases

cell cycle
cell proliferation
signaling pathway
high intensity
papillary thyroid
single cell
squamous cell
cancer therapy
pi k akt
young adults
human health
climate change