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Pediatric pharmacogenomics: challenges and opportunities: on behalf of the Sanford Children's Genomic Medicine Consortium.

David B GregornikDaria SalyakinaMarilyn BrownSamuel RoikoKenneth S Ramos
Published in: The pharmacogenomics journal (2020)
The advent of digital, electronic, and molecular technologies has allowed the study of complete genomes. Integrating this information into drug development has opened the door for pharmacogenomic (PGx) interventions in direct patient care. PGx allows clinicians to better identify drug of choice and optimize dosing regimens based on an individual's genetic characteristics. Integrating PGx into pediatric care is a priority for the Sanford Children's Genomic Medicine Consortium, a partnership of ten children's hospitals across the US committed to the innovation and advancement of genomics in pediatric care. In this white paper, we review the current state of PGx research and its clinical utility in pediatrics, a largely understudied population, and make recommendations for advancing cutting-edge practice in pediatrics.
Keyphrases
  • healthcare
  • young adults
  • palliative care
  • quality improvement
  • copy number
  • emergency department
  • pain management
  • clinical practice
  • adverse drug
  • dna methylation
  • chronic pain