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Glycolysis in Peritubular Endothelial Cells and Microvascular Rarefaction in CKD.

Yujie HuangAnsheng CongJinjin LiZhanmei ZhouHong ZhouCailing SuZuoyu HuFan Fan HouWei Cao
Published in: Journal of the American Society of Nephrology : JASN (2024)
Our study revealed a disrupted regulation of glycolysis in peritubular endothelial cells as an initiator of microvascular rarefaction in CKD. Restoration of peritubular endothelial cell glycolysis in CKD kidney improved microvascular rarefaction and ameliorated fibrotic lesions.
Keyphrases
  • endothelial cells
  • chronic kidney disease
  • high glucose
  • vascular endothelial growth factor
  • systemic sclerosis
  • single cell